Stanford running back Christian McCaffrey and Clemson quarterback Deshaun Watson finished second and third, respectively.
MORE: Top SEC Heisman winners | BRADLEY: Henry’s been a Heisman winner in the making
“I’ve been honored and blessed with this opportunity. Since I was a kid this was a lifelong goal and a dream of mine. I’m just so thankful,” Henry said at the podium after being presented the trophy.
Henry captured 378 of 928 possible first-place votes. McCaffrey was second with 290 first-place votes.
Henry, a junior from Florida, led the nation and set an SEC record with 1,986 rushing yards and 23 touchdowns for the second-ranked Crimson Tide, who are in the College Football Playoff for the second straight year.
PHOTOS: Heisman Trophy winner Derrick Henry
Henry, who joins Mark Ingram as the only Alabama players to have won the award, broke a five-year streak of quarterbacks winning college football’s highest individual honor.
No. 2 Alabama plays No. 3 Michigan State in the Cotton Bowl on New Year’s Eve as part of the College Football Playoff semifinals.